Polycystin 2: A calcium channel, channel partner, and regulator of calcium homeostasis in ADPKD
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چکیده
منابع مشابه
A simulation study of calcium release channel
The IP3R calcium release channel has been simulated using a stochastic simulation algorithm (SSA;Gillespie algorithm) and De young-Keiser model. A set of different concentration for Cat' and IP3 havebeen used. Considering the Number of molecules in each state, a non linear behavior of the system can beseen clearly. The inhibiting role of the Ca+2 on the open state (X110) has been studied. The d...
متن کاملPolycystin-2 is an intracellular calcium release channel.
Polycystin-2, the product of the gene mutated in type 2 autosomal dominant polycystic kidney disease (ADPKD), is the prototypical member of a subfamily of the transient receptor potential (TRP) channel superfamily, which is expressed abundantly in the endoplasmic reticulum (ER) membrane. Here, we show by single channel studies that polycystin-2 behaves as a calcium-activated, high conductance E...
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ژورنال
عنوان ژورنال: Cellular Signalling
سال: 2020
ISSN: 0898-6568
DOI: 10.1016/j.cellsig.2019.109490